Purpose
This study aimed to explore the mediating role of self-transcendence in the relationship between job stress and wellness among nurses based on self-transcendence theory. Methods: A descriptive cross-sectional design was adopted, and data were collected via an online survey using Google Forms from July 22 to August 20, 2024. This study analyzed data from 290 nurses working in 10 hospitals. Correlation and multiple regression analyses were conducted, alongside simple mediation analysis with bootstrapping, to evaluate the mediating role of self-transcendence. All statistical analyses were performed using Jamovi software. Results: Positive correlations were identified among job stress, self-transcendence, and wellness in nurses. Regression analyses revealed that self-transcendence was positively associated with wellness (β=.62, p<.001), while job stress had no significant association with wellness. Mediation analysis demonstrated that self-transcendence significantly mediated the relationship between job stress and wellness (β=.22, p<.001). Conclusion: The findings highlight the influence of self-transcendence on the relationship between job stress and wellness among nurses. This underscores the importance of designing interventions to enhance self-transcendence as a strategy to promote wellness among nurses.