Purpose
This study aimed to identify the influence of nursing professionalism, the nursing work environment, and compassion competence on person-centered care among nurses working in comprehensive nursing care units. Methods: An online survey using structured self-report questionnaires was administered to 190 nurses in comprehensive nursing care units at three tertiary general hospitals. The collected data were analyzed using descriptive statistics, the independent t-test, the Mann-Whitney U-test, one-way analysis of variance, Pearson’s correlation coefficient, and multiple linear regression using SPSS version 29.0 program. Results: The average score for person-centered care was 3.70±0.49, nursing professionalism was 3.56±0.51, the nursing work environment was 2.53±0.46, and compassion competence was 4.01±0.47. Person-centered care demonstrated significant positive correlations with nursing professionalism (r=.636, p<.001), the nursing work environment (r=.542, p<.001), and compassion competence (r=.743, p<.001). Factors influencing person-centered care included compassion competence (β=.56, p<.001), nursing professionalism (β=.21, p<.001), and the nursing work environment (β=.20, p<.001), with an explanatory power of 65.2% (F=118.84, p<.001). Conclusion: To improve person-centered care among nurses in comprehensive nursing care units, it is necessary to strengthen nurses’ compassion competence and professionalism, as well as enhance the nursing work environment. The findings of this study may be used as foundational evidence for developing programs to promote person-centered care in comprehensive nursing care units.